Kanon (2006)

I could possibly be wrong about this, but I believe the 2006 version of this anime is better then the first Kanon anime that was released. In case anyone is wondering or doesn't know, the 2006 version is a remake. This anime is also on 98% of all 'Saddest Anime Ever' lists found online.

Kanon is about a boy named Yuichi Aizawa who moves into his aunt and cousins house to attend high school. He doesn't remember much about the town he used to visit as a kid, but during his stay he meets several girls who he used to know as a kid. As Yuichi helps each girl deal with their own problems he also learns more about his past.

NOTE: An 'Uguu' a day keeps the doctor away.